CAR T-Cell Therapy: An Update for Radiologists
| Autor: | Daniel A. Smith, Sree Harsha Tirumani, Nikhil H. Ramaiya, Paolo Caimi, Justin G. Yoon |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Immunotherapy Adoptive 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Antigen Neoplasms Radiologists medicine Humans Radiology Nuclear Medicine and imaging health care economics and organizations Receptors Chimeric Antigen business.industry General Medicine Immunotherapy medicine.disease Chimeric antigen receptor Lymphoma Cancer treatment Cytokine release syndrome 030220 oncology & carcinogenesis Cancer research CAR T-cell therapy Car t cells business human activities |
| Zdroj: | AJR. American journal of roentgenology. 217(6) |
| ISSN: | 1546-3141 |
| Popis: | Chimeric antigen receptor-engineered (CAR) T-cell therapy is a promising novel immunotherapy that has the potential to revolutionize cancer treatment. Four CAR T-cell therapies have received FDA approval within the last 5 years, and the role of CAR T cells is anticipated to continue to evolve and expand. However, various aspects of CAR T-cell therapies remain poorly understood, and the therapies are associated with severe side effects, including cytokine release syndrome and immune effector cell-associated neurotoxicity, which require prompt diagnosis and intervention. The purposes of this review are to describe the role of imaging in diagnosing and monitoring toxicities from CAR T-cell therapies and explore the use of various imaging techniques, including PET/CT with novel radiotracers, to predict and assess treatment response and adverse effects. It is important for radiologists to recognize the imaging findings associated with each syndrome and to recognize the typical and atypical treatment response patterns associated with CAR T-cell therapy. Given the expected increase in use of CAR T cells in the near future, radiologists should familiarize themselves with the imaging findings encountered in these novel therapies so that they can provide comprehensive and up-to-date guidance for clinical management. |
| Databáze: | OpenAIRE |
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