New Bioactive Taxoids from Cell Cultures of Taxus baccata
| Autor: | Wenwen Ma, Gary L. Park, George A. Gomez, Matthew H. Nieder, Tom L. Adams, John S. Aynsley, Om P. Sahai, Richard J. Smith, Roy W. Stahlhut, Peter J. Hylands, Francis Bitsch, Cedric Shackleton |
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| Rok vydání: | 1994 |
| Předmět: |
Magnetic Resonance Spectroscopy
Paclitaxel Stereochemistry Pharmaceutical Science Tumor cells Human cell line California Mass Spectrometry Analytical Chemistry Tubulin assembly Tubulin Drug Discovery Humans Cytotoxicity Cells Cultured Pharmacology Plants Medicinal biology Chemistry Organic Chemistry biology.organism_classification Selective cytotoxicity Antineoplastic Agents Phytogenic Molecular Weight Complementary and alternative medicine Taxcultine Taxus Cell culture Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Journal of Natural Products. 57:116-122 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np50103a016 |
| Popis: | Four new taxoids were isolated from cell cultures of Taxus baccata. Their structures were elucidated by spectroscopic analyses. Two were the aglycones corresponding to previously isolated 7-O-xylosides of taxol C [1] and 10-deacetyltaxol C [2]. The third [3] had an N-methylated side-chain, while the fourth, named taxcultine [4], contained an n-propyl group on the side-chain. All four compounds actively promoted tubulin assembly. Taxol C [1] showed potent and selective cytotoxicity in the NCI human cell line screen. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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