Activating CD94:NKG2C and inhibitory CD94:NKG2A receptors are expressed by distinct subsets of committed CD8+ TCR alphabeta lymphocytes
| Autor: | Eddy Roosnek, Jean Villard, Bernard Chapuis, Casimir de Rham, Sylvie Degermann, Lionel Arlettaz, Bertrand Huard |
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| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
T cell
C-Type/immunology Immunology Receptors Antigen T-Cell C-C chemokine receptor type 7 Biology CD8-Positive T-Lymphocytes Natural killer cell Interferon-gamma CD/immunology Antigen Antigens CD T-Lymphocyte Subsets Lectins Receptors medicine Immunology and Allergy Humans Lectins C-Type CD8-Positive T-Lymphocytes/immunology/metabolism Receptors Immunologic Antigens Receptor Interferon-gamma/metabolism T-Cell/immunology ddc:616 Immunologic/immunology T-cell receptor T-Lymphocyte Subsets/immunology Cell biology medicine.anatomical_structure Immunologic Memory/immunology Receptors Natural Killer Cell NK Cell Lectin-Like Receptor Subfamily C Natural Killer Cell Immunologic Memory NK Cell Lectin-Like Receptor Subfamily D CD8 |
| Zdroj: | European Journal of Immunology, Vol. 34, No 12 (2004) pp. 3456-64 |
| ISSN: | 0014-2980 |
| Popis: | A subset of CD8(+) T cells express the natural killer cell receptors CD94:NKG2A or CD94:NKG2C. We found that although many CD8(+) T cells transcribe CD94 and NKG2C, expression of a functional CD94:NKG2C receptor is restricted to highly differentiated effector cells. CD94:NKG2A is expressed by a different subset consisting of CCR7(+) memory cells and CCR7(-) effector cells. Since NKG2A can only be induced on naive CD8(+) T cells while CD94(-) memory cells are refractory, it is likely that commitment to the CD94:NKG2A(+) subset occurs during the first encounter with antigen. CCR7(+)CD94:NKG2A(+) T cells recirculate through lymph nodes where upon activation, they produce large quantities of IFN-gamma. These cells occur as a separate CD94:NKG2A(+) T cell lineage with a distinct TCR repertoire that differs from that of the other CD8(+)CD94(-) T cells activated in situ. |
| Databáze: | OpenAIRE |
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