Side-Hole Catheter Placement for Hepatic Arterial Infusion Chemotherapy in Patients with Liver Metastases from Colorectal Cancer: Long-Term Treatment and Survival Benefit
| Autor: | Hiroshi Seki, Toshirou Ozaki, Makoto Shiina |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Peptic Ulcer medicine.medical_specialty Colorectal cancer medicine.medical_treatment Antineoplastic Agents Catheters Indwelling Hepatic Artery Catheterization Peripheral medicine Humans Infusions Intra-Arterial Radiology Nuclear Medicine and imaging Vascular Patency Aged Retrospective Studies Aged 80 and over Chemotherapy business.industry Liver Neoplasms Cancer General Medicine Middle Aged medicine.disease Discontinuation Surgery Survival Rate Catheter medicine.anatomical_structure Female Colorectal Neoplasms Liver cancer Catheter placement business Artery |
| Zdroj: | American Journal of Roentgenology. 190:111-120 |
| ISSN: | 1546-3141 0361-803X |
| Popis: | The objective of this study was to evaluate retrospectively correlations between catheter placement methods and treatment outcomes of patients treated with hepatic arterial infusion chemotherapy for unresectable liver metastases from colorectal cancer.This study involved 135 patients with liver metastases from colorectal cancer who underwent intrahepatic chemotherapy using catheter-port systems. Complications, treatment discontinuation, hepatic progression, and survival of patients treated with each method were evaluated retrospectively using the Kaplan-Meier method. Conventional 5-French end-hole catheter placement (n = 10) was compared with three side-hole catheter placement methods: 5-French side-hole catheter placement with a fixed catheter tip (original fixed catheter tip method, n = 77); long tapered side-hole catheter placement using a fixed catheter tip method (modified fixed catheter tip method, n = 24); and long tapered side-hole catheter inserted distally in the hepatic artery (long tapered catheter placement method, n = 24).The following treatment outcomes were significantly better for patients treated using the original or modified fixed catheter tip or long tapered catheter placement method than for those treated using the conventional method, respectively: hepatic arterial patency (1 year: 76.3%, 95.0%, and 94.4% vs 38.9%; p = 0.0014, 0.0007, and 0.0006), catheter stability (1 year: 96.7%, 95.5%, and 95.2% vs 42.9%; p0.0001, p = 0.0003, and p = 0.0009), time to treatment discontinuation (medians: 11.7, 14.4, and 12.4 vs 3.2 months; p0.0001, 0.0002, and 0.0019), time to hepatic progression (medians: 14.7, 15.7, and 15.8 vs 5.5 months; p = 0.0049, 0.0141, and 0.0004), and overall survival (medians: 21.1, 22.5, and 23.1 vs 13.1 months; p = 0.0146, 0.0036, and 0.0017).Compared with the conventional method, side-hole catheter placement methods allowed long-term intrahepatic chemotherapy and resulted in improved survival. |
| Databáze: | OpenAIRE |
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