Insulin dysregulation in horses with induced obesity
| Autor: | Rafael Resende Faleiros, Rodrigo Ribeiro, Alexandre Augusto de Oliveira Gobesso, Debora da Silva Freitas Ribeiro, Cahuê Francisco Rosa Paz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Mangalarga Marchador horses
medicine.medical_specialty 040301 veterinary sciences medicine.medical_treatment Veterinary medicine obesity induction induced metabolic syndrome 0403 veterinary science Insulin resistance Internal medicine insulin resistance SF600-1100 Hyperinsulinemia Medicine overweight horses General Veterinary biology business.industry Insulin 0402 animal and dairy science Mangalarga 04 agricultural and veterinary sciences Insulin dysregulation biology.organism_classification medicine.disease 040201 dairy & animal science Obesity Endocrinology Basal (medicine) Equine metabolic syndrome Analysis of variance business DIETA ANIMAL |
| Zdroj: | Pesquisa Veterinária Brasileira v.40 n.1 2020 Pesquisa Veterinária Brasileira Colégio Brasileiro de Patologia Animal (CBPA) instacron:EMBRAPA Pesquisa Veterinária Brasileira, Vol 40, Iss 1, Pp 39-45 (2020) Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Insulin deregulation (ID) is a central player in the pathophysiology of equine metabolic syndrome (EMS), which is associated with generalized and/or regional obesity. The objective of this experiment was to characterize the alterations in the hormonal profile in horses exposed to a hypercaloric diet. A total of nine Mangalarga Marchador adult horses with initial body condition score (BCS) of 2.9±1/9 (mean±SD) were submitted to a high calorie grain-rich diet for 5 months. The data was collected before the start of the experiment and every 15 days until the end of the experiment and glucose and insulin concentrations were measured in the plasma. Proxies G:I, RISQI, HOMA-IR and MIRG were calculated. The low-dose oral glucose tolerance test (OGTT) was performed and the total area under the glucose (GTA) and insulin (ITA) curves at three different timepoints (before inducing obesity, after 90 days and after 150 days) was used. Analysis of variance of the results was performed considering the time effects and the means were compared with repeated measures by the Tukey’s test (P≤0.05). The ID was observed during the first 90 days of the experiment and was characterized as a decompensated ID, showing an increase of basal glucose and insulin plasma levels, changes in all proxies and a significant increase in GTA (P |
| Databáze: | OpenAIRE |
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