Anti-asthmatic activity of phenolic compounds from the roots of Gastrodia elata Bl
| Autor: | Ji Yun Lee, Young Woon Jang, Chang Jong Kim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Eosinophil Peroxidase Free Radicals Neutrophils Ovalbumin Immunology Guinea Pigs Pharmacology Benzoates chemistry.chemical_compound Phospholipase A1 Phenols Leukocytes Immunology and Allergy Animals chemistry.chemical_classification Gastrodia biology Plant Extracts Airway Resistance Glycoside Biological activity respiratory system biology.organism_classification Gastrodia elata Asthma Phospholipases A2 chemistry Biochemistry Benzaldehydes biology.protein Cyclooxygenase Eosinophil peroxidase Bronchoalveolar Lavage Fluid Histamine Peroxidase Phytotherapy |
| Zdroj: | International immunopharmacology. 10(2) |
| ISSN: | 1878-1705 |
| Popis: | We previously reported that 4-hydroxy-3-methoxybenzaldehyde has the most potent anti-inflammatory and analgesic activity of eight phenolic compounds obtained from the dried roots of Gastrodiaelata (GE) Blume (Orchidaceae); its activity may be related to inhibition of cyclooxygenase activities and oxidation. In the present study, the effects of nine phenolic compounds from GE on immediate-phase (IAR) and late-phase (LAR) asthmatic responses after aerosolized-ovalbumin (OA) challenge were evaluated by determining the specific airway resistance (sRaw) using a double-chambered plethysmograph in conscious guinea pigs with IgE-mediated asthma. Furthermore, recruitment of leukocytes, histamine release, and eosinophil peroxidase (EPO) and phospholipase A(2) (PLA(2)) activities were determined in bronchoalveolar lavage fluids (BALF) 24h after the antigen challenge. 4-Hydroxy-3-methoxybenzyl alcohol (12.5mg/kg) significantly (p |
| Databáze: | OpenAIRE |
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