Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15
| Autor: | J Eisenman, L S Park, Dirk M. Anderson, David Cosman, K H Grabstein, S Kumaki, A Namen, M Ahdieh, K. Shanebeck, J. G. Giri |
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| Rok vydání: | 1994 |
| Předmět: |
Protein Conformation
Protein subunit Biology General Biochemistry Genetics and Molecular Biology Interleukin 10 receptor alpha subunit Cell Line Structure-Activity Relationship Animals Humans Molecular Biology Interleukin 12 receptor beta 1 subunit G alpha subunit Common gamma chain Interleukin-15 General Immunology and Microbiology General Neuroscience Interleukins Receptors Interleukin-2 Haplorhini Recombinant Proteins Cell biology Interleukin-15 receptor Biochemistry Interleukin 15 Gamma subunit Protein Binding Research Article |
| Zdroj: | The EMBO journal. 13(12) |
| ISSN: | 0261-4189 |
| Popis: | We have recently cloned a novel cytokine, IL-15, with shared bioactivities but no sequence homology with IL-2. We found high affinity IL-15 binding to many cell types, including cells of non-lymphoid origin. Analysis of IL-15 interaction with subunits of the IL-2 receptor (IL-2R) revealed that the alpha subunit was not involved in IL-15 binding. We demonstrated directly in cells transfected with IL-2R subunits that both the beta and gamma chains are required for IL-15 binding and signaling. Hence, IL-15, like IL-2, IL-4 and IL-7, utilizes the common IL-2R gamma subunit found to be defective in X-linked severe combined immunodeficiency in humans. IL-15 is the only cytokine other than IL-2 that has also been shown to share the beta signaling subunit of IL-2R. The differential ability of some cells to bind and respond to IL-2 and IL-15 implies the existence of an additional IL-15-specific component. |
| Databáze: | OpenAIRE |
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