Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology
| Autor: | Carl G. Simon, Alamgir Karim, Eric J. Amis, Hoda M. Elgendy, Newell R. Washburn, Alessandro Tona |
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| Rok vydání: | 2002 |
| Předmět: |
Materials science
Biocompatibility Polymers Surface Properties Polyesters Bone Screws Biomedical Engineering Biocompatible Materials Polyethylene Glycols Biomaterials chemistry.chemical_compound Materials Testing Composite material Porosity Dissolution Cells Cultured chemistry.chemical_classification Osteoblasts Ethylene oxide Viscosity Temperature Biomaterial Polymer Polyethylene chemistry Microscopy Fluorescence Void (composites) Microscopy Electron Scanning Stress Mechanical Rheology Algorithms |
| Zdroj: | Journal of biomedical materials research. 60(1) |
| ISSN: | 0021-9304 |
| Popis: | A methodology for the preparation of porous scaffolds for tissue engineering using co-extrusion is presented. Poly(ϵ-caprolactone) is blended with poly(ethylene oxide) in a twin-screw extruder to form a two-phase material with micron-sized domains. Selective dissolution of the poly(ethylene oxide) with water results in a porous material. A range of blend volume fractions results in co-continuous networks of polymer and void spaces. Annealing studies demonstrate that the characteristic pore size may be increased to larger than 100 μm. The mechanical properties of the scaffolds are characterized by a compressive modulus on the order of 1 MPa at low strains but displaying a marked strain-dependence. The results of osteoblast seeding suggest it is possible to use co-extrusion to prepare polymer scaffolds without the introduction of toxic contaminants. Polymer co-extrusion is amenable to both laboratory- and industrial-scale production of scaffolds for tissue engineering and only requires rheological characterization of the blend components. This method leads to scaffolds that have continuous void space and controlled characteristic length scales without the use of potentially toxic organic solvents. © 2002 Wiley Periodicals, Inc. J Biomed Mater Res 60: 20–29, 2002 |
| Databáze: | OpenAIRE |
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