AWE-somes: All Water Emulsion Bodies with Permeable Shells and Selective Compartments
| Autor: | Daeyeon Lee, Kathleen J. Stebe, Sarah D. Hann |
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| Rok vydání: | 2017 |
| Předmět: |
Chromatography
Materials science Drop (liquid) Aqueous two-phase system Nanoparticle 02 engineering and technology Permeation 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Polyelectrolyte 0104 chemical sciences chemistry.chemical_compound Chemical engineering chemistry Emulsion PEG ratio General Materials Science 0210 nano-technology Ethylene glycol |
| Zdroj: | ACS Applied Materials & Interfaces. 9:25023-25028 |
| ISSN: | 1944-8252 1944-8244 |
| DOI: | 10.1021/acsami.7b05800 |
| Popis: | Living cells exploit compartmentalization within organelles to spatially and temporally control reactions and pathways. Here, we use the all aqueous two phase system (ATPS) of poly(ethylene glycol) (PEG) and dextran to develop all water emulsion bodies, AWE-somes, a new class of encapsulated double emulsions as potential cell mimics. AWE-somes feature rigid polyelectrolyte (PE)/nanoparticle (NP) shells and double emulsion interiors. The shells form via complexation of PE and NP at interfaces of ATPS. The NPs, excluded from the drop phase, create an osmotic stress imbalance that removes water from the encapsulated phase and draws droplets of external PEG phase into the shells to form the double emulsion interior. We demonstrate that molecules can permeate the AWE-some shells, selectively partition into the internal droplets, and undergo reaction. AWE-somes have significant potential for creating functional, biocompatible protocell systems. |
| Databáze: | OpenAIRE |
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