Dual infection with polyomavirus BK and acyclovir-resistant herpes simplex virus successfully treated with cidofovir in a bone marrow transplant recipient
| Autor: | Dominik Selleslag, B. Gordts, Ghislain Opdenakker, Graciela Andrei, Pierre Fiten, Robert Snoeck, Patrick Goubau, E. De Clercq, H van Landuyt |
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| Rok vydání: | 2007 |
| Předmět: |
Tumor Virus Infections
Adolescent animal diseases viruses Organophosphonates Acyclovir Herpesvirus 1 Human Drug resistance medicine.disease_cause Antiviral Agents Virus Cytosine chemistry.chemical_compound Drug Resistance Viral medicine Humans Bone Marrow Transplantation Polyomavirus Infections Transplantation business.industry virus diseases Herpes Simplex medicine.disease Virology BK virus Infectious Diseases Herpes simplex virus chemistry BK Virus Immunology Female business Cidofovir Hemorrhagic cystitis |
| Zdroj: | Transplant Infectious Disease. 9:126-131 |
| ISSN: | 1399-3062 1398-2273 |
| Popis: | A hematopoietic stem cell transplant recipient developed a mucosal herpes simplex virus-1 (HSV-1) infection while under acyclovir (ACV) treatment (HSV was later shown to be resistant to ACV). Concomitantly, the patient presented a hemorrhagic cystitis (HC) due to polyomavirus BK, for which intravenous cidofovir (CDV) was prescribed. The patient benefited from the broad-spectrum anti-DNA virus activity of CDV, and not only the HC resolved without signs of nephrotoxicity but also the HSV-1 lesions disappeared. This is the first report describing the effect of CDV on 2 simultaneous and unrelated DNA viral infections in an immunosuppressed transplant recipient. In addition, we describe here that this HSV-1 isolate possesses a unique phenotype and genotype. |
| Databáze: | OpenAIRE |
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