The Role of Time as a Prognostic Factor in Pediatric Brain Tumors: a Multivariate Survival Analysis
| Autor: | Daniel Eduardo Alvarez-Amado, Juan Carlos García-Beristain, Fernando Chico-Ponce-de-León, Eduardo Javier Barragán-Pérez, Chiharu Murata, Luis Juárez-Villegas, Carlos Enrique Altamirano-Vergara, Vicente González-Carranza |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Prognostic factor Delayed Diagnosis Time Factors Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans CNS TUMORS Risk factor Child Retrospective Studies Multivariate survival analysis Brain Neoplasms business.industry Confounding General Medicine Prognosis Combined Modality Therapy Survival Rate 030104 developmental biology Pediatric brain Child Preschool 030220 oncology & carcinogenesis Female Prospective research Risk of death business Follow-Up Studies |
| Zdroj: | Pathology & Oncology Research. 26:2693-2701 |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/s12253-020-00875-3 |
| Popis: | There is no evidence that prolonged pre diagnostic symptomatic intervals (PSI) increases the risk of death in pediatric brain tumors. When investigating the role of time previous research had not controlled for confounding variables or measured the pretreatment interval (PTI). We use the term global delay interval (GDI) to describe the sum of PSI and PTI. The aim of this research was to evaluate whether there was a decrease in the probability of survival in children with brain tumors due to a prolonged PSI, PTI and GDI, using a multivariate survival analysis. We retrospective review 127 clinical records labeled with the diagnosis of CNS tumors attended at a specialized pediatric center in Mexico City from January 2008 to December 2012. Patients with PSI and GDI diagnosed between 3 and 6 months showed statistical lower probability of surviving that those with intervals |
| Databáze: | OpenAIRE |
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