Accelerated cell cycles enable organ regeneration under developmental time constraints in the Drosophila hindgut
| Autor: | Donald T. Fox, Nora G. Peterson, Erez Cohen, Jessica K. Sawyer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Cell division Organogenesis Mitosis Biology General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mitotic cell cycle Regeneration Animals Drosophila Proteins Molecular Biology Transcription factor SOX Transcription Factors Janus Kinases 030304 developmental biology 0303 health sciences Wound Healing Regeneration (biology) G1 Phase Gene Expression Regulation Developmental Cell Biology Cell cycle Cell biology Gastrointestinal Tract STAT Transcription Factors Drosophila melanogaster chemistry Female Drosophila Ecdysone receptor 030217 neurology & neurosurgery Ecdysone Transcription Factors Developmental Biology |
| Zdroj: | Dev Cell |
| Popis: | Individual organ development must be temporally coordinated with development of the rest of the organism. As a result, cell division cycles in a developing organ occur on a relatively fixed timescale. Despite this, many developing organs can regenerate cells lost to injury. How organs regenerate within the time constraints of organism development remains unclear. Here, we show that the developing Drosophila hindgut regenerates by accelerating the mitotic cell cycle. This process is achieved by decreasing G1 length and requires the JAK/STAT ligand unpaired-3. Mitotic capacity is then terminated by the steroid hormone ecdysone receptor and the Sox transcription factor Dichaete. These two factors converge on regulation of a hindgut-specific enhancer of fizzy-related, a negative regulator of mitotic cyclins. Our findings reveal how the cell-cycle machinery and cytokine signaling can be adapted to accomplish developmental organ regeneration. |
| Databáze: | OpenAIRE |
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