Spatio-temporal concentration of acetylcholine in vertebrate synaptic cleft
| Autor: | Anthony Y. Aidoo, Kim Y. Ward |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Synaptic cleft
Acetylcholinesterase Neuromuscular junction Computer Science Applications chemistry.chemical_compound Nicotinic agonist medicine.anatomical_structure chemistry Modelling and Simulation Modeling and Simulation medicine Biophysics Neurotransmitter Acetylcholine medicine.drug Acetylcholine receptor |
| Zdroj: | Mathematical and Computer Modelling. 44:952-962 |
| ISSN: | 0895-7177 |
| DOI: | 10.1016/j.mcm.2006.03.003 |
| Popis: | The concentration of acetylcholine (ACh) in the synaptic cleft at the neuromuscular junction (NMJ) remains impossible to quantify using direct measurements based upon spatio-temporal resolution. We present a model of the concentration of ACh in the synaptic cleft. Our model considers the release mechanism and the clearance process, represented by the hydrolysis of acetylcholinesterase (AChE) and the rate of diffusion across the cleft and binding to nicotinic ACh receptor channels. Using our model, we evaluate the contribution of these factors and their relative importance in determining the spatial distribution of neurotransmitter concentration in the neuromuscular junction. |
| Databáze: | OpenAIRE |
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