Effect of digoxin on sinus nodal reentry in the dog
| Autor: | Karlen L. Paulay, Anthony N. Damato |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Digoxin
medicine.medical_specialty Heart block Electrocardiography Dogs Internal medicine medicine Animals cardiovascular diseases Sinus (anatomy) Sinoatrial Node medicine.diagnostic_test business.industry Sinoatrial node Digitalis Glycosides Reentry medicine.disease Denervation Heart Block Cardiac nerve medicine.anatomical_structure Anesthesia Cardiology Cardiology and Cardiovascular Medicine business medicine.drug Digitalis Toxicity |
| Zdroj: | The American Journal of Cardiology. 35:370-375 |
| ISSN: | 0002-9149 |
| DOI: | 10.1016/0002-9149(75)90029-6 |
| Popis: | The effect of digoxin on sinus nodal reentry was examined in 20 open chest mongrel dogs during infusion of digoxin at a rate of 2.5 μg/kg per min. The extrinsic cardiac nerve supply was removed acutely in 10 dogs and was left intact in the remaining 10 dogs. Sinus nodal reentry was relatively unaffected by digoxin in 18 of 20 dogs. In these 18 dogs, digitalis toxicity developed before reentry was abolished and was manifested as increased atrial and ventricular automaticity in 14 and as advanced atrioventricular (A-V) block in four. In the remaining two dogs, sinus nodal reentry was relatively sensitive to digoxin and was abolished before toxicity became manifest as advanced A-V block. The knowledge of the relative insensitivity of sinus nodal reentry to digoxin, at least in this experimental model, contrasts with the previously reported sensitivity of sinus nodal reentry to quinidine, and may be important in the management of sinus nodal reentry in man. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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