Nuclear Factor-κB modulates cellular glutathione and prevents oxidative stress in cancer cells
| Autor: | Ying Xia, Zhongyun Dong, Liang Chen, Zhimin Peng, Qinghang Meng, Jutong Si |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Cancer Research Inflammation Biology medicine.disease_cause Article Arsenicals Mice chemistry.chemical_compound Arsenic Trioxide medicine Animals Humans chemistry.chemical_classification Reactive oxygen species Leukemia GCLM NF-kappa B Prostatic Neoplasms Oxides NF-κB Glutathione Molecular biology Oxidative Stress Oncology chemistry Cancer cell Cancer research medicine.symptom Intracellular Oxidative stress Signal Transduction |
| Zdroj: | Cancer Letters. 299:45-53 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2010.08.002 |
| Popis: | The NF-κB is best known for its role in inflammation. Here we show that constitutive NF-κB activity in cancer cells promotes the biosynthesis of redox scavenger glutathione (GSH), which in turn confers resistance to oxidative stress. Inhibition of NF-κB significantly decreases GSH in several lines of human leukemia and prostate cancer cells possessing high or moderate NF-κB activities. Concomitantly, NF-κB inhibition by pharmacological and molecular means sensitizes "NF-κB positive" cancer cells to chemically-induced oxidative stress and death. We propose that inhibition of NF-κB can reduce intracellular GSH in "NF-κB-positive" cancers thereby improving the efficacy of oxidative stress-based anti-cancer therapy. |
| Databáze: | OpenAIRE |
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