Antioxidative metabolism in Down syndrome
| Autor: | Askin Isimer, Bekir Sitki Sayli, Ahmet Aydin, Fulya Tekşen, Ahmet Sayal |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Down syndrome medicine.medical_specialty Antioxidant Adolescent Endocrinology Diabetes and Metabolism medicine.medical_treatment Clinical Biochemistry chemistry.chemical_element Biochemistry Gene dosage Antioxidants Inorganic Chemistry Superoxide dismutase Selenium Internal medicine medicine Humans Child chemistry.chemical_classification Glutathione Peroxidase biology Superoxide Dismutase Glutathione peroxidase Biochemistry (medical) General Medicine medicine.disease Trace Elements Zinc Enzyme Endocrinology chemistry Child Preschool biology.protein Female Down Syndrome Chromosome 21 Copper |
| Zdroj: | Biological trace element research. 63(2) |
| ISSN: | 0163-4984 |
| Popis: | Down syndrome is the most common cause of mental retardation, affecting 1 in 700-800 liveborn infants. Although numerous biochemical abnormalities accompanying the syndrome have not yet been completely clarified, the antioxidant defense system enzymes have shown to be altered due to increased gene dosage on chromosome 21 and overproduction of superoxide dismutase (SOD-1 or Cu/Zn SOD). The purpose of this study was to investigate the activities of SOD-1 and glutathione peroxidase (GSH-Px) enzymes and the levels of their cofactors zinc (Zn), copper (Cu) and selenium (Se) in plasma of 20 Down syndrome patients. In comparison with age and sex-matched controls (n = 15), plasma GSH-Px, SOD, and Cu levels were significantly decreased in the patient group, but Zn and Se concentrations remained unchanged. |
| Databáze: | OpenAIRE |
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