Utilization of Nutmeg (Myristica fragrans Houtt.) Seed Hydrodistillation Time to Produce Essential Oil Fractions with Varied Compositions and Pharmacological Effects
| Autor: | Ekaterina A. Jeliazkova, Mohamed Ibrahim, Valtcho D. Zheljazkov, Tess Astatkie, Charles L. Cantrell |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
sabinene
Pharmaceutical Science Sabinene 01 natural sciences Analytical Chemistry law.invention lcsh:QD241-441 chemistry.chemical_compound myristicin lcsh:Organic chemistry α-terpinene law 0103 physical sciences Drug Discovery Food science Physical and Theoretical Chemistry γ-terpinene Essential oil p-cymene Limonene terpinolene biology camphene 010308 nuclear & particles physics Organic Chemistry Nutmeg 3-carene Regression models biology.organism_classification 0104 chemical sciences Myristicin β-pinene 010404 medicinal & biomolecular chemistry chemistry Chemistry (miscellaneous) Myrcene α-phellandrene α-pinene Molecular Medicine Myristica fragrans Camphene limonene α-thujene myrcene |
| Zdroj: | Molecules Volume 25 Issue 3 Molecules, Vol 25, Iss 3, p 565 (2020) |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules25030565 |
| Popis: | The intent of this study was to utilize distillation timeframes (DT) of nutmeg (Myristica fragrans) essential oil (EO) to generate fractions with differential chemical compositions and bioactivity. Ten fractions were captured at the following distillation timeframes: 0.0&ndash 0.5, 0.5&ndash 1.0, 1.0&ndash 2.5, 2.5&ndash 5.0, 5.0&ndash 10, 10&ndash 30, 30&ndash 60, 60&ndash 90, 90&ndash 120, and 120&ndash 240 min. In addition, a control EO was collected from a straight 0&ndash 240 min non-stop distillation. ANOVA and advanced regression modeling revealed that the produced EO fractions possess substantial variation in the concentration of potentially desired compounds. The concentrations (%) of &alpha phellandrene, 3-carene, p-cymene, limonene, &alpha thujene, &alpha pinene, camphene, sabinene, &beta pinene, and myrcene decreased, while the concentrations (%) of &alpha terpinene, &gamma terpinene, terpinolene, and myristicin increased in later DT fractions. Nutmeg EO showed some antimalarial activity against Plasmodium falciparum D6, but did not exhibit significant antifungal activity. In general, nutmeg seed oil yields increased with an increase of DT. These results may be utilized by industries using nutmeg EO. |
| Databáze: | OpenAIRE |
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