CD2+, CD3-, CD56/NCAM+ malignant lymphoma with TCR beta gene rearrangement: a case report
| Autor: | Gerard T. Simon, Elena Savilo, George L. Frank, Praniti Soamboonsrup, Peter B. Neame, Linda L. Sunisloe, Ralph M. Meyer |
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| Rok vydání: | 1995 |
| Předmět: |
Male
CD3 Complex Lymphoma CD3 Receptors Antigen T-Cell alpha-beta CD2 Antigens chemical and pharmacologic phenomena Biology Natural killer cell Immunophenotyping immune system diseases hemic and lymphatic diseases medicine Humans Gene Rearrangement beta-Chain T-Cell Antigen Receptor Aged T-cell receptor hemic and immune systems Hematology Gene rearrangement medicine.disease Peripheral T-cell lymphoma CD56 Antigen medicine.anatomical_structure Cancer research biology.protein Neural cell adhesion molecule |
| Zdroj: | American journal of hematology. 50(3) |
| ISSN: | 0361-8609 |
| Popis: | A case of CD56/NCAM+ malignant lymphoma is reported. Only a rare malignant lymphoma cell showed azurophilic granules in the cytoplasm of Giesma-stained preparations, while electron microscopic examination revealed occasional cytoplasmic granules with paracrystalline inclusions. The most common phenotype seen in NK lymphomas, CD2+, CD3-, CD56+, CD16-, CD57-, was present in the case. Cases with this phenotype have been interpreted to represent either true NK lymphoma or T-cell lymphoma with NK expression. Genotyping, where performed, has shown TCR germline configuration. Our case showed TCR beta rearrangement indicating that the above phenotype can be associated with a peripheral T-cell lymphoma. |
| Databáze: | OpenAIRE |
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