Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
| Autor: | Roxana Kashani, Laura Melendez-Alafort, Joan Lecina, Jane K. Sosabowski, Jordi Borràs, Joan Suades, Julie Foster |
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| Rok vydání: | 2020 |
| Předmět: |
Single Photon Emission Computed Tomography Computed Tomography
Clinical Biochemistry Pharmaceutical Science chemistry.chemical_element Zinc Technetium 01 natural sciences Biochemistry High-performance liquid chromatography Transmetalation Mice Carbonyl Coordination Complexes Drug Discovery Animals Tissue Distribution Molecular Biology chemistry.chemical_classification Biological studies Transmetallation 010405 organic chemistry Biomolecule Organic Chemistry Rhenium 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Molecular Medicine Radiopharmaceutical Radiopharmaceuticals Nuclear chemistry Cysteine |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona |
| ISSN: | 1464-3405 |
| Popis: | Altres ajuts: acords transformatius de la UAB The transmetalation reaction between zinc dithiocarbamates functionalized with organic groups and the cation fac-[Tc(HO)(CO)] has been studied as a new strategy to bind biomolecules to this radionuclide for preparing radiopharmaceuticals with high molar activity. All complexes were obtained in high yields by heating at moderate temperatures and without subsequent purification. The chemical identity was ascertained by HPLC comparison with the homologous rhenium complexes. Stability studies in cysteine solution and serum have shown a good stability of the coordination set fac-[Tc(CO)(SS)(P)]. Preliminary biological studies of the radiocomplex functionalized with D-(+)-glucosamine with carcinoma cells have been performed. |
| Databáze: | OpenAIRE |
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