The effect of dietary copper on rat plasma apolipoprotein B, E plasma levels, and apolipoprotein gene expression in liver and intestine
| Autor: | Yves Rayssiguier, Fatiha Nassir, Jacques Bellanger, M. Lamand, E. Gueux, Philippe Cardot, A. Mazur |
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| Přispěvatelé: | Unité de recherche Maladies Métaboliques et Micronutriments (U3M), Institut National de la Recherche Agronomique (INRA), Unité de nutrition et métabolisme protéique |
| Rok vydání: | 1992 |
| Předmět: |
Male
Apolipoprotein E medicine.medical_specialty Apolipoprotein B 030309 nutrition & dietetics [SDV]Life Sciences [q-bio] Endocrinology Diabetes and Metabolism Clinical Biochemistry Gene Expression Weanling Biochemistry Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound Apolipoproteins E Internal medicine Hyperlipidemia Gene expression medicine Animals Intestinal Mucosa EXPRESSION GENETIQUE Triglycerides Apolipoproteins B 030304 developmental biology 0303 health sciences biology Triglyceride Biochemistry (medical) Hypertriglyceridemia Rats Inbred Strains General Medicine medicine.disease Rats Endocrinology Liver chemistry biology.protein RAT lipids (amino acids peptides and proteins) Copper deficiency Copper |
| Zdroj: | Biological Trace Element Research Biological Trace Element Research, Humana Press, 1992, 34 (2), pp.107-113. ⟨10.1007/BF02785240⟩ |
| ISSN: | 1559-0720 0163-4984 |
| Popis: | International audience; The plasma levels of apo B and apo E, and the level of hepatic and intestinal mRNA coding for these apolipoproteins were investigated in weanling male rats pair-fed for 6 wk with a control or copperdeficient diet. Plasma cholesterol, triglycerides, and phospholipids were significantly increased, and plasma apo B and apo E levels were also markedly increased in copper-deficient rats as compared to control rats. Copper deficiency significantly increased triglyceride levels and decreased cholesterol levels in the liver. No major differences in the levels of hepatic and intestinal apo B and apo E mRNA occurred between control and copper-deficient rats. These data imply that hypertriglyceridemia dn hypercholesterolemia owing to the copper deficiency are not accompanied by modifications in the gene expression at the mRNA level in the liver and intestine of the apolipoproteins studied. |
| Databáze: | OpenAIRE |
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