How far musicality and perfect pitch are derived from genetic factors?
| Autor: | Krzysztof Szyfter, Michał Witt |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Receptors Vasopressin Human Genetics • Review Gene Dosage Inheritance Patterns Biology Amusia Pitch Discrimination 03 medical and health sciences 0302 clinical medicine Chromosome (genetic algorithm) Genetic linkage Chromosome regions Genetics medicine Humans Absolute pitch Copy-number variation Serotonin Plasma Membrane Transport Proteins General Medicine medicine.disease Cadherins Human genetics humanities Protocadherins Musicality GATA2 Transcription Factor 030104 developmental biology Genes Evolutionary biology Twin Studies as Topic Carbohydrate Epimerases 030217 neurology & neurosurgery Music |
| Zdroj: | Journal of Applied Genetics |
| ISSN: | 2190-3883 |
| Popis: | There is an agreement about joint genetic and environmental background of musical reception and performance. Musical abilities tend to cluster in families. The studies done on a random population, twins and families of gifted musicians provided a strong support for genetic contribution. Modern biomolecular techniques exploring linkage analysis, variation of gene copy number, scanning for whole-genome expression helped to identify genes, or chromosome regions associated with musical aptitude. Some studies were focused on rare ability to recognize tone without reference that is known as a perfect pitch where a far ethnic differentiation was established. On the other hand, gene deletion leading to dysfunction in amusical individuals also indicated appropriate loci “by negation.” The strongest support for an association of genes with musicality was provided for genes: AVPR1 (12q14.2), SLC6A4 (17q11.2), GALM (2p22), PCDH7 (4p15.1), GATA2 (3q21.3), and few others as well for 4q22, 4q23, and 8q13–21 chromosome bands. |
| Databáze: | OpenAIRE |
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