Relationships between chemical changes and histological damage in the brains of scrapie affected mice
| Autor: | J.S. Slater, D.L. Mould, I. Zlotnik, A.McL. Dawson |
|---|---|
| Rok vydání: | 1967 |
| Předmět: |
medicine.medical_specialty
Pathology Hydrolyzed protein Sodium Potassium chemistry.chemical_element Nerve Tissue Proteins Scrapie Brain damage Body weight Hippocampus Pathology and Forensic Medicine Mice Internal medicine medicine Animals Dry matter Amino Acids Medulla Oblongata Sheep General Veterinary Body Weight Brain Organ Size Endocrinology chemistry Spongy degeneration Female medicine.symptom |
| Zdroj: | Journal of Comparative Pathology. 77:393-403 |
| ISSN: | 0021-9975 |
| DOI: | 10.1016/0021-9975(67)90024-2 |
| Popis: | An attempt has been made to correlate chemical changes with the degree and extent of histological damage in mouse brains infected with the “Suffolk strain” of scrapie. A scheme is described for the combined grading of degree of brain damage and distribution of lesions based on neuronal vacuolation and spongy degeneration. Considerable variation was found in the extent to which the mice were affected with scrapie. There was good correlation between change in body weight and histological grading and also a progressive decrease in brain weight with increase in extent of lesions. A slight decrease in mean density of brain tissue was observed. Total dry matter and protein concentrations remained constant. The sodium concentration remained constant, but there was 5 per cent. decrease in potassium concentration. A rise in acid proteinase activity appeared at the same time as minimal lesions, but reached a maximum before widespread lesions were present. There were no gross changes in the concentration of total free amino-acids. Since the total dry matter and protein concentrations alter very little, excess products of protein hydrolysis arising from increased acid proteinase activity must be removed rapidly from the brain. It is possible that the release of waste products may occur in sudden localised outbursts. |
| Databáze: | OpenAIRE |
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