The Continuous Infusion of Recombinant Activated Factor VIIa (rFVIIa) in Patients with Factor VIII Inhibitors Activates the Coagulation and Fibrinolytic Systems without Clinical Complications
| Autor: | R. Redaelli, G. Mostarda, Francesco Baudo, Gabriella Somaini, Francesco de Cataldo, Teresa Maria Caimi |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male Catheterization Central Venous medicine.medical_treatment Factor VIIa Hemophilia A Fibrin Fibrinogen Degradation Products Sepsis chemistry.chemical_compound Bolus (medicine) Isoantibodies medicine Coagulopathy Humans Infusions Intravenous Blood Coagulation Aged Factor IX Hematoma Chemotherapy Factor VIII Factor VII Platelet Count Septic shock business.industry Fibrinolysis Fibrinogen Hematology Middle Aged medicine.disease Peptide Fragments Recombinant Proteins Catheter chemistry Anesthesia Female Prothrombin business medicine.drug |
| Zdroj: | Thrombosis Research. 99:21-24 |
| ISSN: | 0049-3848 |
| Popis: | The standard modality of administration of rFVIIa to patients with FVIII and FIX inhibitors is the intermittent infusion every 2 to 6 hours. No untoward local or systemic effects have been reported; laboratory data of activation of coagulation were reported in the presence of coexistent problems (sepsis, septic shock) or with high doses. We treated four patients with FVIII inhibitor with rFVIIa administered by continuous infusion by a central vein catheter, monitoring the signs of systemic activation of the hemostatic system. The F1+2 prothrombin fragments and the D-dimer increased after the bolus, and remained above the baseline values throughout the treatment period. These variations observed during the infusion period were not accompanied by clinical events. |
| Databáze: | OpenAIRE |
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