Measuring the dynamic mechanical response of hydrated mouse bone by nanoindentation
| Autor: | Karl J. Jepsen, Haviva M. Goldman, Hayden William Courtland, J. Gregory Swadener, Siddhartha Pathak, Surya R. Kalidindi |
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| Rok vydání: | 2011 |
| Předmět: |
Materials science
Bone density Mice Inbred A Biomedical Engineering Modulus 02 engineering and technology In Vitro Techniques Bone tissue Article Bone and Bones Viscoelasticity Biomaterials Mice 03 medical and health sciences Species Specificity Bone Density Indentation medicine Animals Nanotechnology Desiccation Elasticity (economics) 030304 developmental biology 0303 health sciences Tissue Embedding Viscosity Biomechanics Water Anatomy Nanoindentation 021001 nanoscience & nanotechnology Elasticity Biomechanical Phenomena Mice Inbred C57BL medicine.anatomical_structure Mechanics of Materials Collagen 0210 nano-technology Biomedical engineering |
| Zdroj: | Journal of the Mechanical Behavior of Biomedical Materials. 4:34-43 |
| ISSN: | 1751-6161 |
| DOI: | 10.1016/j.jmbbm.2010.09.002 |
| Popis: | This study demonstrates a novel approach to characterizing hydrated bone’s viscoelastic behavior at the lamellar length scales using dynamic indentation techniques. We studied the submicron-level viscoelastic response of bone tissue from two different inbred mouse strains, A/J and B6, with known differences in whole bone and tissue-level mechanical properties. Our results show that bone having a higher collagen content or a lower mineral-to-matrix ratio demonstrates a trend towards a larger viscoelastic response. When normalized for anatomical location relative to biological growth patterns in the antero-medial (AM) cortex, bone tissue from B6 femora, known to have a lower mineral-to-matrix ratio, is shown to exhibit a significantly higher viscoelastic response compared to A/J tissue. Newer bone regions with a higher collagen content (closer to the endosteal edge of the AM cortex) showed a trend towards a larger viscoelastic response. Our study demonstrates the feasibility of this technique to be used to study local composition-property relationships in bone. Further, this technique of viscoelastic nanoindentation mapping of the bone surface at these submicron length scales is shown to be highly advantageous in studying sub-surface features, such as porosity, of wet hydrated biological specimens, which are difficult to identify using other methods. |
| Databáze: | OpenAIRE |
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