Roles of microRNAs in carbohydrate and lipid metabolism disorders and their therapeutic potential
| Autor: | Samantha Pérez Uribe, Luis Aarón Manzanero Cárdenas, Sujay Paul, María Fernanda Ruíz Aguilar, Luis Alberto Bravo Vázquez, Ashutosh Sharma, Samik Chakraborty |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Regulation of gene expression Lipid Metabolism Disorder 030102 biochemistry & molecular biology Fatty liver Lipid Metabolism Disorders Lipid metabolism General Medicine Carbohydrate metabolism Biology medicine.disease Biochemistry Cell biology Disease Models Animal Mice MicroRNAs 03 medical and health sciences Metabolic pathway 030104 developmental biology Insulin resistance microRNA medicine Animals Humans Glucose Metabolism Disorders |
| Zdroj: | Biochimie. 187:83-93 |
| ISSN: | 0300-9084 |
| DOI: | 10.1016/j.biochi.2021.05.015 |
| Popis: | MicroRNAs (miRNAs) are small (∼21 nucleotides), endogenous, non-coding RNA molecules implicated in the post-transcriptional gene regulation performed through target mRNA cleavage or translational inhibition. In recent years, several investigations have demonstrated that miRNAs are involved in regulating both carbohydrate and lipid homeostasis in humans and other organisms. Moreover, it has been observed that the dysregulation of these metabolism-related miRNAs leads to the development of several metabolic disorders, such as type 2 diabetes, obesity, nonalcoholic fatty liver, insulin resistance, and hyperlipidemia. Hence, in this current review, with the aim to impulse the research arena of the micro-transcriptome implications in vital metabolic pathways as well as to highlight the remarkable potential of miRNAs as therapeutic targets for metabolic disorders in humans, we provide an overview of the regulatory roles of metabolism-associated miRNAs in humans and murine models. |
| Databáze: | OpenAIRE |
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