Insertion/Deletion and Nucleotide Polymorphism Data Reveal Constraints in Drosophila melanogaster Introns and Intergenic Regions
| Autor: | David De Lorenzo, Lino Ometto, Wolfgang Stephan |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Genetics
Polymorphism Genetic Models Genetic biology Nucleic acid sequence Intron Single-nucleotide polymorphism Investigations biology.organism_classification Noncoding DNA Introns chemistry.chemical_compound Drosophila melanogaster Intergenic region Species Specificity chemistry Polymorphism (computer science) DNA Transposable Elements Animals DNA Sequence Deletion |
| Zdroj: | Genetics. 169:1521-1527 |
| ISSN: | 1943-2631 |
| Popis: | Our study of nucleotide sequence and insertion/deletion polymorphism in Drosophila melanogaster noncoding DNA provides evidence for selective pressures in both intergenic regions and introns (of the large size class). Intronic and intergenic sequences show a similar polymorphic deletion bias. Insertions have smaller sizes and higher frequencies than deletions, supporting the hypothesis that insertions are selected to compensate for the loss of DNA caused by deletion bias. Analysis of a simple model of selective constraints suggests that the blocks of functional elements located in intergenic sequences are on average larger than those in introns, while the length distribution of relatively unconstrained sequences interspaced between these blocks is similar in intronic and intergenic regions. |
| Databáze: | OpenAIRE |
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