A randomized cross-over trial to detect differences in arm volume after low- and heavy-load resistance exercise among patients receiving adjuvant chemotherapy for breast cancer at risk for arm lymphedema:study protocol
| Autor: | Peter Oturai, Tom Møller, Karl Bach Christensen, Kira Bloomquist, Bent Ejlertsen, Lis Adamsen, Sandi Hayes |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
Cancer Research Activities of daily living Visual analogue scale Breast Cancer Lymphedema Population Breast Neoplasms Severity of Illness Index 03 medical and health sciences Study Protocol 0302 clinical medicine Breast cancer Activities of Daily Living Genetics Journal Article Medicine Humans Prospective Studies Lymphedema Prospective cohort study education education.field_of_study Cross-Over Studies business.industry Resistance Training 030229 sport sciences medicine.disease Crossover study Resistance exercise Exercise Therapy Treatment Outcome Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis Physical therapy Lymph Node Excision Female Exercise prescription business |
| Zdroj: | Bloomquist, K, Hayes, S, Adamsen, L, Møller, T, Christensen, K B, Ejlertsen, B & Oturai, P 2016, ' A randomized cross-over trial to detect differences in arm volume after low-and heavy-load resistance exercise among patients receiving adjuvant chemotherapy for breast cancer at risk for arm lymphedema : study protocol ', B M C Cancer, vol. 16, 517 . https://doi.org/10.1186/s12885-016-2548-y BMC Cancer |
| DOI: | 10.1186/s12885-016-2548-y |
| Popis: | Background In an effort to reduce the risk of breast cancer-related arm lymphedema, patients are commonly advised to avoid heavy lifting, impacting activities of daily living and resistance exercise prescription. This advice lacks evidence, with no prospective studies investigating arm volume changes after resistance exercise with heavy loads in this population. The purpose of this study is to determine acute changes in arm volume after a session of low- and heavy-load resistance exercise among women undergoing adjuvant chemotherapy for breast cancer at risk for arm lymphedema. Methods/Design This is a randomized cross-over trial. Participants: Women receiving adjuvant chemotherapy for breast cancer who have undergone axillary lymph node dissection will be recruited from rehabilitation centers in the Copenhagen area. Intervention: Participants will be randomly assigned to engage in a low- (two sets of 15–20 repetition maximum) and heavy-load (three sets of 5–8 repetition maximum) upper-extremity resistance exercise session with a one week wash-out period between sessions. Outcome: Changes in extracellular fluid (L-Dex score) and arm volume (ml) will be assessed using bioimpedance spectroscopy and dual-energy x-ray absorptiometry, respectively. Symptom severity related to arm lymphedema will be determined using a visual analogue scale (heaviness, swelling, pain, tightness). Measurements will be taken immediately pre- and post-exercise, and 24- and 72-hours post-exercise. Sample size: A sample size of 20 participants was calculated based on changes in L-Dex scores between baseline and 72-hours post exercise sessions. Discussion Findings from this study are relevant for exercise prescription guidelines, as well as recommendations regarding participating in activities of daily living for women following surgery for breast cancer and who may be at risk of developing arm lymphedema. Trial registration Current Controlled Trials ISRCTN97332727. Registered 12 February 2015. Electronic supplementary material The online version of this article (doi:10.1186/s12885-016-2548-y) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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