Effect of Metabolic Stress on Lysosomal Proteolysis in the Liver and Brain of Rats Receiving Q10-Enriched Ration
| Autor: | V. M. Zhminchenko, A. V. Vasil’ev, N. V. Kirbaeva, N. E. Sharanova |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Food deprivation Ubiquinone Biology Cathepsin D General Biochemistry Genetics and Molecular Biology Cathepsin B 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stress Physiological Internal medicine medicine Animals Metabolic Stress Rats Wistar Coenzyme Q10 Lysosomal proteolysis Brain General Medicine Adaptation Physiological Diet Rats 030104 developmental biology Endocrinology Liver chemistry Cathepsin B activity Dietary Supplements Proteolysis Adaptation Food Deprivation Lysosomes 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 165:307-310 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-018-4156-0 |
| Popis: | Activation of lysosomal proteolysis and increased coenzyme Q10 level were revealed in the liver and brain of rats with individual typological features under conditions of food deprivation. Changes in cathepsin B activity in these tissues were different in behaviorally active and passive animals. We observed indirect modulating effect of coenzyme Q10 in the regulation of activity of lysosomal endopeptidases in the brain of animals with different behavior during adaptation to metabolic stress. |
| Databáze: | OpenAIRE |
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