Modulation of α-interferon's antiviral and clinical effects by aspirin, acetaminophen, and prednisone in healthy volunteers

Autor: Craig W. Hendrix, Brent G. Petty, Amina S. Woods, Whaijen Soo, Paul S. Lietman, Frank R. Witter, Diane E. Griffin, Steven K. Kuwahara
Rok vydání: 1995
Předmět:
Zdroj: Antiviral Research. 28:121-131
ISSN: 0166-3542
DOI: 10.1016/0166-3542(95)00043-l
Popis: The magnitude and duration of the antiviral and clinical effect of alpha-interferon was measured in healthy volunteers. A single 3 million unit intramuscular dose of interferon was given either alone (controls) or after 72 h of concomitant medications. These medications included either aspirin (650 mg every 4 h), acetaminophen (650 mg every 4 h), or prednisone (40 mg per day). Peripheral blood mononuclear cells were assayed for resistance to vesicular stomatitis virus infection and induction of 2'-5'-oligoadenylate synthetase activity as evidence of interferon's antiviral effect. Co-administration of acetaminophen increased both antiviral parameters by more than 70% (P0.05) and reduced symptoms after interferon dosing, compared to controls. Aspirin and prednisone did not demonstrate any significant differences from controls in antiviral effect. As a group, acetaminophen, aspirin, and prednisone reduced the clinical symptoms by 47% compared to controls (P = 0.03) after interferon dosing, although individual drug comparisons failed to reach statistical significance. Independent of treatment group, the changes in antiviral markers after interferon dosing correlated closely with each other (r = 0.72, P0.001), but neither correlated with symptoms or fever (r0.30, P0.05). Acetaminophen enhances the antiviral effects of a single intramuscular dose of alpha-interferon, considering the parameters measured in these healthy volunteers.
Databáze: OpenAIRE
Externí odkaz: