Paradoxical immune reconstitution inflammatory syndrome due to toxoplasmic encephalitis: two cases and review of initiation of antiretroviral timing in toxoplasmic encephalitis IRIS
| Autor: | Elizabeth Y. Chiao, Andrew R. DiNardo, J. Clay Goodman, Hoonmo L. Koo, Douglas Smoot Lewis, Roberto A. Andrade |
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| Rok vydání: | 2013 |
| Předmět: |
Immune & Inflammatory Rheumatic Diseases (inc. Arthritis)
Toxoplasma encephalitis urologic and male genital diseases Early initiation General Biochemistry Genetics and Molecular Biology Immune reconstitution inflammatory syndrome Acquired immunodeficiency syndrome (AIDS) Infectious Diseases of the Nervous System medicine Toxoplasmic encephalitis cardiovascular diseases Clinical Practice Article General Pharmacology Toxicology and Pharmaceutics HIV Infection & AIDS: Clinical General Immunology and Microbiology urogenital system business.industry fungi Articles General Medicine medicine.disease Antiretroviral therapy female genital diseases and pregnancy complications Toxoplasmosis Immunology business |
| Zdroj: | F1000Research |
| ISSN: | 2046-1402 |
| DOI: | 10.12688/f1000research.2-133.v1 |
| Popis: | Toxoplasma encephalitis immune reconstitution inflammatory syndrome (TE-IRIS) is rare and usually occurs in an unmasking, rather than paradoxical form. To the best of our knowledge, only two cases of paradoxical TE-IRIS and nine cases of unmasking TE-IRIS have been previously described. We present two additional cases of histopathology-consistent paradoxical TE-IRIS, after early initiation of antiretroviral therapy (ART), and review the literature on TE-IRIS. Three of the four reported cases of paradoxical TE-IRIS were associated with early (within one week) initiation of ART, an issue that was not addressed in the 2009 US Department of Health and Human Services guidelines for the treatment of opportunistic infections. |
| Databáze: | OpenAIRE |
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