Simultaneous determination of captopril and hydrochlorothiazide by time-resolved chemiluminescence with artificial neural network calibration
| Autor: | Min Sun, Zhen-Zhong Zhang, Xiao-Feng Yang, Hua Li, Han-Chun Yao |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Analyte
Original article Combined use Analytical chemistry Pharmaceutical Science Pharmacy Pharmaceutical formulation Analytical Chemistry law.invention Chemometrics Hydrochlorothiazide law Drug Discovery Electrochemistry Calibration medicine Spectroscopy Chemiluminescence Medicine(all) Chemistry Biochemistry Genetics and Molecular Biology(all) lcsh:RM1-950 Captopril time-resolved chemiluminescence hydrochlorothiazide captopril lcsh:Therapeutics. Pharmacology artificial neural network medicine.drug |
| Zdroj: | Journal of Pharmaceutical Analysis, Vol 1, Iss 1, Pp 32-38 (2011) Journal of Pharmaceutical Analysis |
| ISSN: | 2095-1779 |
| Popis: | The combined use of chemometrics and chemiluminescence (CL) measurements, with the aid of the stopped-flow mixing technique, developed a simple time-resolved CL method for the simultaneous determination of captopril (CPL) and hydrochlorothiazide (HCT). The stopped-flow technique in a continuous-flow system was employed in this work in order to emphasize the kinetic differences between the two analytes in cerium (IV)-rhodamine 6G CL system. After the flow was stopped, an initial rise of CL signal was observed for HCT standards, while a direct decay of CL signal was obtained for CPL standards. The mixed CL signal was monitored and recorded on the whole process of continuousflow/stopped-flow, and the obtained data were processed by the chemometric approach of artificial neural network. The relative prediction error (RPE) of CPL and HCT was 5.9% and 8.7%, respectively. The recoveries of CPL and HCT in tablets were found to fall in the range between 95% and 106%. The proposed method was successfully applied to the simultaneous determination of CPL and HCT in a compound pharmaceutical formulation. Keywords: time-resolved chemiluminescence, artificial neural network, captopril, hydrochlorothiazide |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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