Improvement of seminal quality and sexual function of men with oligoasthenoteratozoospermia syndrome following supplementation with L-arginine and Pycnogenol®
| Autor: | Yuko Sadaoka, Kojiro Nishio, Hiroshi Okada, Keisuke Suzuki, Takeshi Shin, Toshiyuki Iwahata, Gaku Arai, Yoshitomo Kobori, Ryo Sato, Peter Rohdewald, Shigehiro Soh, Jeffry Michael Strong, Hiroshi Yagi |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Arginine Urology lcsh:RC870-923 Asthenozoospermia Spermatogenesis erectile dysfunction L-arginine Pycnogenol Antioxidants Male infertility Nitric oxide chemistry.chemical_compound Erectile Dysfunction Internal medicine medicine Humans Flavonoids biology business.industry Plant Extracts Middle Aged lcsh:Diseases of the genitourinary system. Urology medicine.disease Sperm Spermatozoa Nitric oxide synthase Drug Combinations Endocrinology Erectile dysfunction Treatment Outcome chemistry biology.protein business Sexual function |
| Zdroj: | Archivio Italiano di Urologia e Andrologia, Vol 87, Iss 3, Pp 190-193 (2015) |
| ISSN: | 1124-3562 |
| Popis: | We evaluated the effectiveness of antioxidant co-supplementation therapy using Larginine and Pycnogenol® in Japanese men with oligoasthenozoospermia and mild erectile dysfunction (ED). A total of forty-seven adult males with oligoasthenoteratozoospermia syndrome (OAT) were eligible for enrollment. The effectiveness of supplementation with a combination of L-arginine 690 mg and French maritime pine bark extract (Pycnogenol®) 60mg for OAT and ED was investigated. The sperm concentration was enhanced significantly after treatment 2 and 4 months (11.79 ± 9.86 to 21.22 ± 28.17 and 20.15 ± 23.99 × 106/ml). Significant improvements in the International Index of Erectile Function (IIEF) were observed in the total score of IIEF (57.69 ± 11.04 to 59.43 ± 12.57) and domain of Orgasmic Function (9.01 ± 1.92 to 9.34 ± 1.66) after 4 months of treatment. L-arginine acts to increase the production of nitric oxide and Pycnogenol® activates the endothelial nitric oxide synthase and it is a potent antioxidant and inhibitor of inducible nitric oxide synthase. This study suggests that the combination of Pycnogenol® and L-arginine (Edicare®) is helpful for infertile men to ameliorate simultaneously quality of sperms as well as erectile functions. |
| Databáze: | OpenAIRE |
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