Evaluating the promise of inclusion of African ancestry populations in genomics
| Autor: | Charles N. Rotimi, Amy R. Bentley, Shawneequa L. Callier |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Inclusion (disability rights) lcsh:QH426-470 media_common.quotation_subject Genomic research lcsh:Medicine Genomics Context (language use) Review Article Genome-wide association studies 03 medical and health sciences 0302 clinical medicine Human biology Genetics Molecular Biology Genetics (clinical) media_common business.industry lcsh:R Environmental ethics Personalized medicine Health equity lcsh:Genetics 030104 developmental biology Geography business human activities 030217 neurology & neurosurgery Diversity (politics) |
| Zdroj: | npj Genomic Medicine, Vol 5, Iss 1, Pp 1-9 (2020) NPJ Genomic Medicine |
| ISSN: | 2056-7944 |
| Popis: | The lack of representation of diverse ancestral backgrounds in genomic research is well-known, and the resultant scientific and ethical limitations are becoming increasingly appreciated. The paucity of data on individuals with African ancestry is especially noteworthy as Africa is the birthplace of modern humans and harbors the greatest genetic diversity. It is expected that greater representation of those with African ancestry in genomic research will bring novel insights into human biology, and lead to improvements in clinical care and improved understanding of health disparities. Now that major efforts have been undertaken to address this failing, is there evidence of these anticipated advances? Here, we evaluate the promise of including diverse individuals in genomic research in the context of recent literature on individuals of African ancestry. In addition, we discuss progress and achievements on related technological challenges and diversity among scientists conducting genomic research. |
| Databáze: | OpenAIRE |
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