Neurophysiological and biochemical changes evoked by valproic acid in the central nervous system
| Autor: | Sandra Evans, Dita Cotariu, Jacob L. Zaidman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Taurine
Valproic Acid General Neuroscience medicine.medical_treatment Glutamate receptor Brain Pharmacology medicine.disease nervous system diseases chemistry.chemical_compound Epilepsy Anticonvulsant Agent Anticonvulsant chemistry medicine Animals Humans lipids (amino acids peptides and proteins) Serotonin Neurotransmitter gamma-Aminobutyric Acid medicine.drug |
| Zdroj: | Progress in Neurobiology. 34:343-354 |
| ISSN: | 0301-0082 |
| DOI: | 10.1016/0301-0082(90)90010-e |
| Popis: | (1) Valproic acid is an anticonvulsant agent widely used in the management of various forms of epilepsy, including absence, myoclonic and tonic-clonic seizures. (2) It also has anticonvulsant potency in a wide variety of animal models of epilepsy. (3) This action is generally thought to be exerted through modulation of the activity of the endogenous inhibitory neurotransmitter, γ-aminobutyric acid. (4) Evidence that valproic acid interacts with the γ-aminobutyric acid system is presented. (5) Interactions of valproic acid with other neurotransmitters, i.e. aspartate, glutamate, taurine, serotonin, as well as with cyclic nucleotides and hormones are also considered. (6) Direct effects of valproic acid on excitable membranes and its relationships with analgesia are outlined. |
| Databáze: | OpenAIRE |
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