A Scoring System for Predicting the Prognosis of Late-Onset Severe Pneumonia after Allogeneic Hematopoietic Stem Cell Transplantation
| Autor: | Feng-Rong Wang, Lan-Ping Xu, Ting-Ting Han, Chen-Hua Yan, Le-Qing Cao, Yu-Hong Chen, Xiao-Jun Huang, Jun Kong, Yu-Qian Sun, Ying-Jun Chang, Huan Chen, Xiao-Hui Zhang, Wei Han, Yao Chen, Jing-Rui Zhou, Kai-Yan Liu, Xiao-Dong Mo, Yi-Fei Cheng, Xiao-Su Zhao, Zhi-Dong Wang, Jing-Zhi Wang, Yuan-Yuan Zhang, Yu Wang |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Multivariate analysis medicine.medical_treatment Late onset Hematopoietic stem cell transplantation Gastroenterology Immune system Internal medicine medicine Humans Transplantation Homologous Immunology and Allergy Blood urea nitrogen Retrospective Studies Transplantation Framingham Risk Score business.industry Hematopoietic Stem Cell Transplantation Albumin Pneumonia Cell Biology Hematology Prognosis medicine.disease Molecular Medicine business |
| Zdroj: | Transplantation and Cellular Therapy. 27:870.e1-870.e7 |
| ISSN: | 2666-6367 |
| DOI: | 10.1016/j.jtct.2021.06.031 |
| Popis: | Late-onset severe pneumonia (LOSP) is defined as severe pneumonia developing during the late phase of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Because of the high mortality in patients with LOSP, it is important to identify prognostic factors. In this study, we aimed to develop a risk score system with broad applicability that can help predict the risk of LOSP-associated mortality. We retrospectively analyzed 100 patients with LOSP after allo-HSCT between June 2009 and July 2017. The assessment variables included immune, nutritional, and metabolic parameters at the onset of LOSP. Of these 100 patients, 45 (45%) eventually died, and 55 (55%) were positive for organisms, most commonly viruses. In the multivariate analysis, higher monocyte count (≥0.20 × 109/L versus |
| Databáze: | OpenAIRE |
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