Differences in heart rate variability and body composition in breast cancer survivors and women without cancer
Autor: | Adriana Cristina Pliego-Carrillo, Angel Gómez-Villanueva, Alexandra Estela Soto-Pina, José de Jesús Garduño-García, José Javier Reyes-Lagos, Daniel Escutia-Reyes, Gerardo Emilio-López-Chávez |
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Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Physiology Science Body water RR interval Breast Neoplasms 030204 cardiovascular system & hematology Article 03 medical and health sciences Breast cancer 0302 clinical medicine Metabolic age Cancer Survivors Heart Rate Internal medicine medicine Humans Heart rate variability Survivors Breast Density Cancer Multidisciplinary business.industry Health care Diagnostic markers medicine.disease Computational biology and bioinformatics Sample entropy 030220 oncology & carcinogenesis Concomitant Body Composition Cardiology Medicine Female business Biomedical engineering Biomarkers Neuroscience |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021) |
ISSN: | 2045-2322 |
Popis: | The aim of this study was to explore cardiac autonomic changes assessed by linear and nonlinear indexes of heart rate variability (HRV) and body composition modifications in breast cancer survivors and cancer-free control women. Women who were breast cancer survivors (BCS, n = 27) and without cancer with similar characteristics (Control, n = 31) were recruited for this study. We calculated some relevant linear and nonlinear parameters of 5 min of RR interval time series such as mean RR interval (RRave), the corrected Poincaré index (cSD1/SD2), the sample entropy (SampEn), the long-term fractal scaling exponent (α2) and 2UV from symbolic dynamics. Additionally, we indirectly assessed body composition measures such as body weight, fat mass, visceral fat rating (VFR), normalized VRF (nVFR), muscle mass, metabolic age, and total body water. We found that diverse HRV indexes and only one body composition measure showed statistical differences (p ave: 729 (648–802) vs. 795 (713–852) ms; cSD2/SD1: 3.4 (2.7–5.0) vs. 2.9 (2.3–3.5); SampEn: 1.5 (1.3–1.8) vs. 1.7 (1.5–1.8); α2: 0.6 (0.3–0.6) vs. 0.5 (0.4–0.5); 2UV: 7.1 (4.3–11.5) vs. 10.8 (6.4–15.7) and nVFR 0.12 (0.11–0.13) vs. 0.10 (0.08–0.12) points/kg, respectively. The nVFR was strongly significantly correlated with several indexes of HRV only in the BCS group.Our findings suggest that BCS exhibit lower parasympathetic cardiac activity and changes in HRV patterns compared to Controls. A concomitant increase of visceral fat, among other factors, may contribute to cardiac autonomic disturbances and changes in HRV patterns in BCS. |
Databáze: | OpenAIRE |
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