A simple polyol-free synthesis route to Gd2O3 nanoparticles for MRI applications: an experimental and theoretical study
| Autor: | Patrick Norman, Linnéa Selegård, Joanna Kauczor, Mathieu Linares, Kajsa Uvdal, Per-Olov Käll, Fredrik Söderlind, Maria Ahrén |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Gadolinium oxide
Materials science Gadolinium chemistry.chemical_element Nanoparticle Bioengineering Synthesis Nuclear magnetic resonance Polyol Teknik och teknologier medicine XPS General Materials Science Chelation cardiovascular diseases chemistry.chemical_classification medicine.diagnostic_test Toxicity Magnetic resonance imaging General Chemistry Condensed Matter Physics Atomic and Molecular Physics and Optics chemistry Modeling and Simulation cardiovascular system IR Engineering and Technology Relaxivity |
| ISSN: | 2008-0301 |
| Popis: | Chelated gadolinium ions, e. g., GdDTPA, are today used clinically as contrast agents for magnetic resonance imaging (MRI). An attractive alternative contrast agent is composed of gadolinium oxide nanoparticles as they have shown to provide enhanced contrast and, in principle, more straightforward molecular capping possibilities. In this study, we report a new, simple, and polyol-free way of synthesizing 4-5-nm-sized Gd2O3 nanoparticles at room temperature, with high stability and water solubility. The nanoparticles induce high-proton relaxivity compared to Gd-DTPA showing r(1) and r(2) values almost as high as those for free Gd3+ ions in water. The Gd2O3 nanoparticles are capped with acetate and carbonate groups, as shown with infrared spectroscopy, near-edge X-ray absorption spectroscopy, X-ray photoelectron spectroscopy and combined thermogravimetric and mass spectroscopy analysis. Interpretation of infrared spectroscopy data is corroborated by extensive quantum chemical calculations. This nanomaterial is easily prepared and has promising properties to function as a core in a future contrast agent for MRI. Funding Agencies|VINNOVA|2008-03011|Centre in Nanoscience and Technology at LiTH (CeNano)||Swedish research council|621-2010-5014|SERC (Swedish e-Science Research Center) |
| Databáze: | OpenAIRE |
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