Brimonidine-LAPONITE® intravitreal formulation has an ocular hypotensive and neuroprotective effect throughout 6 months of follow-up in a glaucoma animal model
| Autor: | José M. Fraile, Elena García-Martín, Silvia Mendez-Martinez, T. Ramirez, Maria Jesus Rodrigo, Manuel Subias, C. Luna, José A. Mayoral, Teresa Martinez-Rincon, Jesús Ruberte, Eugenio Vispe, Maria Jose Cardiel, Vicente Polo |
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| Přispěvatelé: | Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Instituto de Salud Carlos III |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
genetic structures Biomedical Engineering Glaucoma Ocular hypertension 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology Medicine Animals General Materials Science Ganglion cell layer 030304 developmental biology 0303 health sciences Retina medicine.diagnostic_test business.industry Brimonidine Silicates Retinal Intravitreal administration medicine.disease eye diseases Rats medicine.anatomical_structure Neuroprotective Agents chemistry Brimonidine Tartrate 030221 ophthalmology & optometry sense organs business medicine.drug Electroretinography Follow-Up Studies |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname Zaguán. Repositorio Digital de la Universidad de Zaragoza |
| ISSN: | 2047-4849 |
| Popis: | Intravitreal administration is widely used in ophthalmological practice to maintain therapeutic drug levels near the neuroretina and because drug delivery systems are necessary to avoid reinjections and sight-threatening side effects. However, currently there is no intravitreal treatment for glaucoma. The brimonidine-LAPONITE® formulation was created with the aim of treating glaucoma for extended periods with a single intravitreal injection. Glaucoma was induced by producing ocular hypertension in two rat cohorts: [BRI-LAP] and [non-bri], with and without treatment, respectively. Eyes treated with brimonidine-LAPONITE® showed lower ocular pressure levels up to week 8 (p < 0.001), functional neuroprotection explored by scotopic and photopic negative response electroretinography (p = 0.042), and structural protection of the retina, retinal nerve fibre layer and ganglion cell layer (p = 0.038), especially on the superior-inferior axis explored by optical coherence tomography, which was corroborated by a higher retinal ganglion cell count (p = 0.040) using immunohistochemistry (Brn3a antibody) up to the end of the study (week 24). Furthermore, delayed neuroprotection was detected in the contralateral eye. Brimonidine was detected in treated rat eyes for up to 6 months. Brimonidine-LAPONITE® seems to be a potential sustained-delivery intravitreal drug for glaucoma treatment. This paper was supported by the Rio Hortega Research Grant M17/00213, PI17/01726, PI17/01946 (Instituto de Salud Carlos III), and by MAT2017-83858-C2-2 MINECO/AEI/ERDF, EU. |
| Databáze: | OpenAIRE |
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