Direct C−H Arylation of Indole‐3‐Acetic Acid Derivatives Enabled by an Autonomous Self‐Optimizing Flow Reactor
| Autor: | Eric Wimmer, N. Vasudevan, Daniel Cortés-Borda, Mireia Rodriguez-Zubiri, François-Xavier Felpin, Elvina Barré |
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| Přispěvatelé: | Chimie Et Interdisciplinarité : Synthèse, Analyse, Modélisation (CEISAM), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Indole test
010405 organic chemistry Chemistry [CHIM.ORGA]Chemical Sciences/Organic chemistry Direct C-H arylation General Chemistry Flow chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound Flow (mathematics) Indole Self-Optimizing flow reactor Indole-3-acetic acid Autonomous synthesis |
| Zdroj: | Advanced Synthesis and Catalysis Advanced Synthesis and Catalysis, Wiley-VCH Verlag, 2021, 363 (3), pp.791-799. ⟨10.1002/adsc.202001217⟩ |
| ISSN: | 1615-4150 1615-4169 |
| DOI: | 10.1002/adsc.202001217⟩ |
| Popis: | International audience; Described herein is a continuous‐flow strategy for the palladium‐catalyzed direct C−H arylation of indole‐3‐acetic acid derivatives with arenediazonium salts. A fully autonomous self‐optimizing flow platform was used to efficiently optimize the coupling reaction in a three‐dimensional space. The flow methodology developed is experimentally simple, mild, broad in scope, and safer than traditional batch approaches. Our continuous‐flow approach is particularly convenient to prepare precursors of pharmaceutically relevant compounds. |
| Databáze: | OpenAIRE |
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