Growth of Infants Fed Formula with Evolving Nutrition Composition: A Single-Arm Non-Inferiority Study
| Autor: | Andreas Nydegger, Philippe Steenhout, Johannes Spalinger, Dominique Charles Belli, Delphine Egli, Raoul I. Furlano, Jerome Tanguy, Jian Yan, Frédéric Destaillats, Sophie Pecquet |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pediatrics Pediatric Obesity First year of life Body Height/ethnology Body Mass Index Child Development Cohort Studies Female Follow-Up Studies Growth Charts Head Humans Infant Formula/adverse effects Infant Newborn Lost to Follow-Up Nutritive Value Overweight/epidemiology Overweight/ethnology Overweight/etiology Patient Dropouts/ethnology Pediatric Obesity/epidemiology Pediatric Obesity/ethnology Pediatric Obesity/etiology Risk Factors Switzerland/epidemiology Urban Health/ethnology Weight Gain/ethnology World Health Organization human milk WHO growth standard evolving nutritional composition infant formula personalized nutrition protein staged‐formula delivery system Weight Gain Non inferiority Medicine Nutrition and Dietetics staged-formula delivery system lcsh:Nutrition. Foods and food supply Switzerland Cohort study medicine.medical_specialty Patient Dropouts lcsh:TX341-641 Article 03 medical and health sciences Lost to follow-up 030109 nutrition & dietetics business.industry Urban Health Anthropometry Composition (combinatorics) Overweight Body Height Infant formula business Body mass index Food Science |
| Zdroj: | Nutrients Nutrients, Vol 9, Iss 3, p 219 (2017) Nutrients, vol. 9, no. 3, pp. E219 Nutrients; Volume 9; Issue 3; Pages: 219 |
| ISSN: | 2072-6643 |
| Popis: | The nutritional composition of human milk evolves over the course of lactation, to match the changing needs of infants. This single-arm, non-inferiority study evaluated growth against the WHO standards in the first year of life, in infants consecutively fed four age-based formulas with compositions tailored to infants’ nutritional needs during the 1st, 2nd, 3rd–6th, and 7th–12th months of age. Healthy full-term formula-fed infants (n = 32) were enrolled at ≤14 days of age and exclusively fed study formulas from enrollment, to the age of four months. Powdered study formulas were provided in single-serving capsules that were reconstituted using a dedicated automated preparation system, to ensure precise, hygienic preparation. The primary outcome was the weight-for-age z-score (WAZ) at the age of four months (vs. non-inferiority margin of −0.5 SD). Mean (95% CI) z-scores for the WAZ (0.12 (−0.15, 0.39)), as well as for the length-for-age (0.05 (−0.19, 0.30)), weight-for-length (0.16 (−0.16, 0.48)), BMI-for-age (0.11 (−0.20, 0.43)), and head circumference-for-age (0.41 (0.16, 0.65)) at the age of four months, were non-inferior. Throughout the study, anthropometric z-scores tracked closely against the WHO standards (within ±1 SD). In sum, a four-stage, age-based infant formula system with nutritional compositions tailored to infants’ evolving needs, supports healthy growth consistent with WHO standards, for the first year of life. |
| Databáze: | OpenAIRE |
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