Neuro-Cardio Mechanisms in Huntington's Disease and Other Neurodegenerative Disorders
| Autor: | Bethan J. Critchley, Mark Isalan, Michal Mielcarek |
|---|---|
| Přispěvatelé: | Wellcome Trust, Medical Research Council (MRC) |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Nervous system Physiology Cardiomyopathy INHIBITION heart failure Neurological disorder Disease Review METABOLISM lcsh:Physiology 03 medical and health sciences 0302 clinical medicine Huntington's disease PARKINSONS-DISEASE Physiology (medical) Huntingtin Protein Medicine TRANSGENIC MOUSE MODEL Pathological PRESENILIN GENES ARRHYTHMIAS Science & Technology DESMIN-RELATED CARDIOMYOPATHY lcsh:QP1-981 business.industry neuro-cardio disorders medicine.disease DYSFUNCTION ALZHEIMERS-DISEASE 030104 developmental biology medicine.anatomical_structure Heart failure HEART-FAILURE CNS business Neuroscience Life Sciences & Biomedicine cardiomyopathy 030217 neurology & neurosurgery Huntington’s disease |
| Zdroj: | Frontiers in Physiology Frontiers in Physiology, Vol 9 (2018) |
| ISSN: | 1664-042X |
| Popis: | Although Huntington’s disease is generally considered to be a neurological disorder, there is mounting evidence that heart malfunction plays an important role in disease progression. This is perhaps not unexpected since both cardiovascular and nervous systems are strongly connected — both developmentally and subsequently in health and disease. This connection occurs through a system of central and peripheral neurons that control cardiovascular performance, while in return the cardiovascular system works as a sensor for the nervous system to react to physiological events. Hence, given their permanent interconnectivity, any pathological events occurring in one system might affect the second. In addition, some pathological signals from Huntington’s disease might occur simultaneously in both the cardiovascular and nervous systems, since mutant Huntingtin protein is expressed in both. Here we aim to review the source of HD-related cardiomyopathy in the light of recently-published studies, and to identify similarities between HD-related cardiomyopathy and other neuro-cardio disorders. |
| Databáze: | OpenAIRE |
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