Oligolactate-grafted dextran hydrogels: Detection of stereocomplex crosslinks by X-ray diffraction
| Autor: | C.F. van Nostrum, Loes M. J. Kroon-Batenburg, S. J. de Jong, Wim E. Hennink, J. J. Kettenes-van den Bosch |
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| Přispěvatelé: | Advanced drug delivery systems/drug targeting, Kristal- en structuurchemie, Massaspectrometrie, Universiteit Utrecht, Dep Farmaceutische wetenschappen, Dep Scheikunde |
| Rok vydání: | 2002 |
| Předmět: |
Pharmacology
Aqueous solution Materials science Polymers and Plastics Dispersity Farmacie(FARM) technology industry and agriculture macromolecular substances General Chemistry Biomedische technologie en medicijnen complex mixtures Oligomer Surfaces Coatings and Films Lactic acid Farmacie/Biofarmaceutische wetenschappen (FARM) chemistry.chemical_compound Crystallinity Dextran chemistry International Self-healing hydrogels Polymer chemistry Medical technology Materials Chemistry Chirality (chemistry) |
| Zdroj: | Journal of Applied Polymer Science. 86:289-293 |
| ISSN: | 1097-4628 0021-8995 |
| DOI: | 10.1002/app.10954 |
| Popis: | Physically crosslinked hydrogels are formed upon mixing equal amounts of aqueous solutions of dextran grafted with L-lactic acid oligomers and dextran grafted with D-lactic acid oligomers. In this paper, the dex-lactate hydrogels are analyzed by X-ray diffraction to provide evidence that hydrogel formation occurred through stereocomplex formation. First, the stereocomplex formation of monodisperse lactic acid oligomers was studied and comparison with published results of poly(lactic acid) was made. It was clearly demonstrated that stereocomplexes were formed between oligomers of opposite chirality. The data for these monodisperse lactic acid oligomers were used to interpret the results obtained with the dex-lactate hydrogels. X-ray diffraction measurements demonstrated that in the hydrogels stereocomplexes were formed between the lactic acid oligomers of opposite chirality. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 86: 289–293, 2002 |
| Databáze: | OpenAIRE |
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