Is the fasting calcium/creatinine a bone resorption marker in patients with calcium renal stones?
| Autor: | Miguel Angel Arrabal-Polo, Sergio Merino-Salas, Armando Zuluaga-Gomez, Encarnacion Cardenas-Grande, Antonio Poyatos-Andujar, Miguel Arrabal-Martin |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Bone density Urology Osteoporosis chemistry.chemical_element Calcium Bone resorption chemistry.chemical_compound Kidney Calculi Internal medicine medicine Humans Bone Resorption Femoral neck Aged Creatinine business.industry Fasting Middle Aged medicine.disease Peptide Fragments Osteopenia Endocrinology medicine.anatomical_structure chemistry Female Collagen business Densitometry Biomarkers |
| Zdroj: | Urological research. 40(3) |
| ISSN: | 1434-0879 |
| Popis: | Osteoporosis and osteopenia are an important endocrine-metabolic disease that affect women and men from a certain age and it has a high risk and health cost. The aim of this short communication is to show that fasting calcium/creatinine ratio in patients with calcium stones is a marker of bone resorption.We studied 180 patients with renal stones with calcium composition and the relationship of them between the calcium/creatinine in urine after 8 h of fasting with bone densitometry (T-score) and values of bone resorption marker β-crosslaps (ng/ml). The Pearson correlation test was applied for the analysis of linear correlations between quantitative variables.We have observed a statistically significant positive linear correlation between the fasting calcium/creatinine and serum and β-crosslaps (R = 0.534, p < 0.0001) and a statistically significant negative linear correlation between fasting calcium/creatinine and T-score of bone densitometry in hip (R = −0.237, p = 0.002), femoral neck (R = −0.217, p = 0.009) and lumbar spine (R = 0.292, p = 0.001).The fasting ratio calcium/creatinine in urine is associated with increased levels of β-crosslaps marker and therefore may be useful as a marker of bone resorption in these patients. |
| Databáze: | OpenAIRE |
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