Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension

Autor: Elias Marum, Heno Ferreira Lopes, Luciano F. Drager, Fernanda Fatureto-Borges, Sandra H. Teixeira, Raimundo Jenner, Eduardo M. Krieger, Luiz Aparecido Bortolotto, Dante A.M. Giorgi, Valeria Costa-Hong, Fernanda Marciano Consolim-Colombo, Geraldo Lorenzi-Filho
Rok vydání: 2016
Předmět:
Male
Endocrinology
Diabetes and Metabolism
Angiotensin-Converting Enzyme Inhibitors
Blood Pressure
Polysomnography
030204 cardiovascular system & hematology
0302 clinical medicine
Hydrochlorothiazide
Enalapril
Risk Factors
Sleep Apnea and Hypertension
030212 general & internal medicine
Diuretics
Pulse wave velocity
Sleep Apnea
Obstructive
medicine.diagnostic_test
Sleep apnea
SEXO
Blood Pressure Monitoring
Ambulatory
Middle Aged
Cardiovascular Diseases
Echocardiography
Hypertension
Cardiology
Female
Cardiology and Cardiovascular Medicine
Brazil
medicine.drug
Adult
medicine.medical_specialty
Ambulatory blood pressure
Pulse Wave Analysis
Losartan
03 medical and health sciences
Vascular Stiffness
Internal medicine
Internal Medicine
medicine
Humans
Aged
business.industry
medicine.disease
respiratory tract diseases
Obstructive sleep apnea
Blood pressure
Arterial stiffness
business
Angiotensin II Type 1 Receptor Blockers
Zdroj: J Clin Hypertens (Greenwich)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
ISSN: 1751-7176
Popis: Whether sex influences the association of obstructive sleep apnea (OSA) with markers of cardiovascular risk in patients with hypertension is unknown. In this study, 95 hypertensive participants underwent carotid-femoral pulse wave velocity, 24-hour ambulatory blood pressure monitoring, echocardiogram, and polysomnography after a 30-day standardized treatment with hydrochlorothiazide plus enalapril or losartan. OSA was present in 52 patients. Compared with non-OSA patients, pulse wave velocity values were higher in the OSA group (men: 11.1±2.2 vs 12.7±2.4 m/s, P=.04; women: 11.8±2.4 vs 13.2±2.2 m/s, P=.03). The proportion of diastolic dysfunction was significant in men and women with OSA. Compared with non-OSA patients, nondipping systolic blood pressure in OSA was higher in men (14.3% vs 46.4%) and in women (41.4% vs 65.2%). OSA was independently associated with pulse wave velocity (β=1.050; P=.025) and nondipping systolic blood pressure (odds ratio, 3.03; 95% confidence interval, 1.08-8.55; P=.035) in the regression analysis. In conclusion, OSA is independently associated with arterial stiffness and nondipping blood pressure in patients with hypertension regardless of sex.
Databáze: OpenAIRE
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