LC3-associated phagocytosis in microbial pathogenesis
| Autor: | Paul Walther, Ger van Zandbergen, Stefan A. Schille, Peter Crauwels, Katrin Bagola, Rebecca Bohn |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Phagocytosis Microorganism Vacuole Microbiology Pathogenesis 03 medical and health sciences Immune system Phagosomes Animals Humans Parasites Phagosome Immune Evasion biology Bacteria digestive oral and skin physiology Autophagy Fungi General Medicine biology.organism_classification Cell biology 030104 developmental biology Infectious Diseases Vacuoles human activities Microtubule-Associated Proteins |
| Zdroj: | International journal of medical microbiology : IJMM. 308(1) |
| ISSN: | 1618-0607 |
| Popis: | Phagocytosis is essential for uptake and elimination of pathogenic microorganisms. Autophagy is a highly conserved mechanism for incorporation of cellular constituents to replenish nutrients by degradation. Recently, parts of the autophagy machinery - above all microtubule-associated protein 1 light chain 3 (LC3) - were found to be specifically recruited to phagosomal membranes resulting in phagosome-lysosome fusion and efficient degradation of internalized cargo in a process termed LC3-associated phagocytosis (LAP). Many pathogenic bacterial, fungal and parasitic microorganisms reside within LAP-targeted single-membrane phagosomes or vacuoles after infection of host cells. In this minireview we describe the state of knowledge on the interaction of pathogens with LAP or LAP-like pathways and report on various pathogens that have evolved strategies to circumvent degradation in LAP compartments. |
| Databáze: | OpenAIRE |
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