Effects of ethanolic extracts of leaf, seed and fruit of Datura metel L. on kidney function of male albino rats
| Autor: | Chukwuma S. Ezeonu, Yumanang G. Sallah, N. C. Azubuike, Ojochenemi E. Yakubu, Kayode A. Arowora, Chukwumaobim D. Nwokwu, Chinedu Imo |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Original article Histology Sodium 0211 other engineering and technologies lcsh:Medicine chemistry.chemical_element Renal function 02 engineering and technology Biology Kidney 01 natural sciences chemistry.chemical_compound Electrolytes Internal medicine 021105 building & construction medicine Inflammation lcsh:R biology.organism_classification medicine.disease 0104 chemical sciences Cellular infiltration 010404 medicinal & biomolecular chemistry Endocrinology medicine.anatomical_structure Complementary and alternative medicine chemistry Creatinine increased Urea Datura metel |
| Zdroj: | Journal of Traditional and Complementary Medicine Journal of Traditional and Complementary Medicine, Vol 9, Iss 4, Pp 271-277 (2019) |
| ISSN: | 2225-4110 |
| Popis: | Effects of ethanolic extracts of leaf, seed and fruit of Datura metel on kidney function of male albino rats was investigated in this study. The result showed a non-significant (p > 0.05) increase of urea concentration in groups 2 and 3 administered low (300 mg/kg bw) and high (600 mg/kg bw) dose of leaf extract respectively and a non-significant (p > 0.05) decrease in all groups administered the seed and fruit extracts compared with normal control (group 1). Creatinine increased significantly (p 0.05) in all groups administered the various extracts, except in group 4 in which sodium reduced non-significantly (p > 0.05) compared with normal control. Chloride increased significantly (p 0.05) in groups 3, 6 and 7, but reduced non-significantly (p > 0.05) in group 4 compared with normal control. The administration of some of the extracts in comparison with the normal control in histology of the animals show glomerular extrusion and glomerular collapse with resultant increased urinary space, dilated tubules, vacuolations in some epithelial lining of most of the tubules in the medulla and inflammatory cellular infiltration at some peritubular regions. The results showed that some parts of Datura metel posed mild negative effects, while some parts could possess nephroprotective potential by regulating the kidney function of male albino rats. Graphical abstract Image 1 |
| Databáze: | OpenAIRE |
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