Liposteroid Therapy for Refractory Seizures in Children
| Autor: | Yoshihiko Oda, Hideto Yoshikawa, Tokinari Abe, Sawako Yamazaki |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Male
Refractory seizures medicine.medical_specialty Pediatrics Symptomatic West syndrome Anti-Inflammatory Agents Dexamethasone 03 medical and health sciences Epilepsy 0302 clinical medicine 030225 pediatrics medicine Humans Adverse effect business.industry Brain Infant Electroencephalography West Syndrome medicine.disease Surgery Early Infantile Epileptic Encephalopathy Treatment Outcome Rheumatoid arthritis Pediatrics Perinatology and Child Health Female Neurology (clinical) Tomography X-Ray Computed business Spasms Infantile 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Child Neurology. 15:702-704 |
| ISSN: | 1708-8283 0883-0738 |
| DOI: | 10.1177/088307380001501014 |
| Popis: | Liposteroid is dexamethasone palmitate incorporated into liposomes and was developed as an anti-inflammatory drug for targeting therapy mainly for rheumatoid arthritis. Recently, it was reported that liposteroid might be effective for the treatment of West syndrome, with fewer side effects than those of corticotropin therapy. We describe three patients, a 2-month-old boy with early infantile epileptic encephalopathy, a 4-month-old girl with symptomatic West syndrome, and a 2-year-old girl with symptomatic localization-related epilepsy, whose refractory seizures were treated with liposteroid according to the original method reported by Yamamoto and colleagues in 1998. Uncontrollable seizures ceased completely in two patients and the seizure frequency decreased markedly in the other patient. Electroencephalograms revealed marked improvement in all patients. They showed no relapse of the seizures, and all showed no adverse effects except for mild brain shrinkage in one patient. Our experience with these three patients suggests that liposteroid therapy might be a new option for the treatment of refractory seizures in children, as well as for West syndrome. (J Child Neurol 2000;15:702-704). |
| Databáze: | OpenAIRE |
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