Intravoxel incoherent motion imaging has the possibility to detect liver abnormalities in young Fontan patients with good hemodynamics
| Autor: | Kojiro Ono, Akira Shirayama, Takumi Ookubo, Ryo Inuzuka, Kazuhiro Shiraga, Hiroko Asakai, Hiromichi Nakajima, Kouji Higashi |
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| Rok vydání: | 2019 |
| Předmět: |
Heart Defects
Congenital Liver Cirrhosis Male Cirrhosis Adolescent medicine.medical_treatment Liver fibrosis Cardiac index Hemodynamics 030204 cardiovascular system & hematology Fontan Procedure 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Image Processing Computer-Assisted medicine Humans Prospective Studies Child Intravoxel incoherent motion Cardiac catheterization business.industry General Medicine medicine.disease Catheter Diffusion Magnetic Resonance Imaging Pediatrics Perinatology and Child Health Feasibility Studies Female Cardiology and Cardiovascular Medicine business Nuclear medicine Perfusion |
| Zdroj: | Cardiology in the Young. 29:898-903 |
| ISSN: | 1467-1107 1047-9511 |
| Popis: | Introduction:Liver fibrosis and cirrhosis are one of the critical complications in Fontan patients. However, there are no well-established non-invasive and quantitative techniques for evaluating liver abnormalities in Fontan patients. Intravoxel incoherent motion diffusion-weighted imaging with MRI is a non-invasive and quantitative method to evaluate capillary network perfusion and molecular diffusion. The objective of this study is to assess the feasibility of intravoxel incoherent motion imaging in evaluating liver abnormalities in Fontan children.Materials and Methods:Five consecutive Fontan patients and four age-matched healthy volunteers were included. Fontan patients were 12.8 ± 1.5 years old at the time of MRI scan. Intravoxel incoherent motion imaging parameters (D, D*, and f values) within the right hepatic lobe were compared. Laboratory test, ultrasonography, and cardiac MRI were also conducted in the Fontan patients. Results of cardiac catheterization conducted within one year of the intravoxel incoherent motion imaging were also examined.Results:In Fontan patients, laboratory test and liver ultrasonography showed almost normal liver condition. Cardiac catheter and MRI showed good Fontan circulation. Cardiac index was 2.61 ± 0.23 L/min/m2. Intravoxel incoherent motion imaging parameters D, D*, and f values were lower in Fontan patients compared with controls (D: 1.1 ± 0.0 versus 1.3 ± 0.2 × 10−3 mm2/second (p = 0.04), D*: 30.8 ± 24.8 versus 113.2 ± 25.6 × 10−3 mm2/second (p < 0.01), and f: 13.2 ± 3.1 versus 22.4 ± 2.4% (p < 0.01), respectively).Conclusions:Intravoxel incoherent motion imaging is feasible for evaluating liver abnormalities in children with Fontan circulation. |
| Databáze: | OpenAIRE |
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