Risk factors and outcomes associated with anastomotic leaks following esophagectomy: a systematic review and meta-analysis
| Autor: | Sivesh K. Kamarajah, Yashvi Bharwada, Aaron Lin, Dmitri Nepogodiev, Thahesh Tharmaraja, Pritam Singh, Richard P T Evans, Ewen A. Griffiths, James R. Bundred |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Esophageal Neoplasms medicine.medical_treatment Psychological intervention Anastomotic Leak 030230 surgery 03 medical and health sciences 0302 clinical medicine Informed consent Internal medicine medicine Humans Risk factor business.industry Gastroenterology General Medicine Perioperative Esophageal cancer medicine.disease Esophagectomy 030220 oncology & carcinogenesis Meta-analysis Risk Adjustment Complication business |
| Zdroj: | Diseases of the Esophagus. 33 |
| ISSN: | 1442-2050 1120-8694 |
| DOI: | 10.1093/dote/doz089 |
| Popis: | SummaryAnastomotic leaks (AL) are a major complication after esophagectomy. This meta-analysis aimed to determine identify risks factors for AL (preoperative, intra-operative, and post-operative factors) and assess the consequences to outcome on patients who developed an AL. This systematic review was performed according to PRISMA guidelines, and eligible studies were identified through a search of PubMed, Scopus, and Cochrane CENTRAL databases up to 31 December 2018. A meta-analysis was conducted with the use of random-effects modeling and prospectively registered with the PROSPERO database (Registration CRD42018130732). This review identified 174 studies reporting outcomes of 74,226 patients undergoing esophagectomy. The overall pooled AL rates were 11%, ranging from 0 to 49% in individual studies. Majority of studies were from Asia (n = 79). In pooled analyses, 23 factors were associated with AL (17 preoperative and six intraoperative). AL were associated with adverse outcomes including pulmonary (OR: 4.54, CI95%: 2.99–6.89, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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