Prognostic impact of admission high-sensitivity C-reactive protein in acute myocardial infarction patients with and without diabetes mellitus

Autor: Valentina Milazzo, Piergiuseppe Agostoni, Giancarlo Marenzi, Jeness Campodonico, Katia Celentano, Maria Luisa Biondi, Daniela Riggio, Maurizio Rondinelli, Nicola Cosentino, Alice Bonomi, Monica De Metrio, Nicolò Capra, Fabrizio Veglia, Stefano Genovese, Mara Rubino, Claudia Lucci, Antonio L. Bartorelli
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Male
lcsh:Diseases of the circulatory (Cardiovascular) system
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Population
Shock
Cardiogenic
Pulmonary Edema
Acute myocardial infarction
Risk Assessment
Diabetes mellitus
Patient Admission
Predictive Value of Tests
Risk Factors
Internal medicine
Clinical endpoint
Medicine
Humans
Myocardial infarction
Hospital Mortality
Prospective Studies
education
Non-ST Elevated Myocardial Infarction
Angiology
Original Investigation
Aged
Inflammation
Aged
80 and over
education.field_of_study
biology
business.industry
Incidence (epidemiology)
Cardiogenic shock
Incidence
C-reactive protein
Middle Aged
medicine.disease
Prognosis
Up-Regulation
High-sensitivity C-reactive protein
C-Reactive Protein
lcsh:RC666-701
biology.protein
ST Elevation Myocardial Infarction
Female
Inflammation Mediators
Cardiology and Cardiovascular Medicine
business
Biomarkers
Zdroj: Cardiovascular Diabetology
Cardiovascular Diabetology, Vol 19, Iss 1, Pp 1-13 (2020)
ISSN: 1475-2840
Popis: Background High-sensitivity C-reactive protein (hs-CRP) elevation frequently occurs in acute myocardial infarction (AMI) and is associated with adverse outcomes. Since diabetes mellitus (DM) is characterized by an underlying chronic inflammation, hs-CRP may have a different prognostic power in AMI patients with and without DM. Methods We prospectively included 2064 AMI patients; hs-CRP was measured at hospital admission. Patients were grouped according to hs-CRP quartiles and DM status. The primary endpoint was a composite of in-hospital mortality, cardiogenic shock, and acute pulmonary edema. Two-year all-cause mortality was the secondary endpoint. Results Twenty-six percent (n = 548) of patients had DM and they had higher hs-CRP levels than non-DM patients (5.32 vs. 3.24 mg/L; P Conclusions This study shows that hs-CRP predicts in-hospital outcome and two-year mortality in AMI patients with and without DM. However, in DM patients, the same risk of developing events as in non-DM patients is associated to higher hs-CRP levels.
Databáze: OpenAIRE
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